What is Stone Man Syndrome ?

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What is Stone Man Syndrome ? How can Stone Man Syndrome be cured ?

Stone Man Syndrome, which occurs in approximately 2,500 people around the world, is a disease caused by a mutation in genes in regions 23 and 24 of the q (long) arm of chromosome 2. Stone Man Syndrome is the disruption of the connective tissue (specialized tissues that bind the tissues) in the body, especially under pressure and impact. Those with this syndrome cannot do physical activity, because with every blow they take, the area where they are hit is ossified. In addition, medical interventions such as biopsy and vaccination accelerate the petrification process. People with this disease cannot even perform simple operations such as hair combing, hanging and taking off their coats due to petrification. Now let’s take a closer look at this disease that makes life difficult to live.

FOP, or Fibrodysplasia Ossificans Progressiva ( gradual ossification of connective tissue ) causes the connective tissue to turn into bone. The reason for this is that the body repair mechanism is damaged as a result of a mutation. The gene with the mutation is the ACVR1 gene. As a result of this mutation, endothelial cells turn into impregnated bone marrow cells and they turn into bone. As a result of the injuries, those parts start to freeze and become ossified.

The mutation that causes this genetic disease occurs spontaneously in the gametes. And individuals with this disease usually don’t have children.

Stone Man Syndrome was formerly known as Myositis Ossificans Progressiva (“ossification of muscles”). However, research has shown that not only the muscles but also the entire connective tissue can turn into bones. Therefore, in 1970, the name of this disease was changed to Fibrodysplasia Ossificans Progressiva.

The most prominent common feature of children born with FOP is a deformed large toe. The process called “flare up”, which causes pain and lasts for 6-8 weeks, first occurs around the age of 10. Bone growth is from top to bottom as in fetuses.

FOP typically first appears in the dorsal, axial, cranial, and proximal parts of the body, then progresses to the ventral, appendicular, tail, and distal regions.

The gene that causes ossification is deactivated when it comes out of the mother’s womb, but this gene is active in FOP patients. For this reason, ossification is seen.

In patients with abnormal bone formation, lymphocytes containing excess bone, which are formed as a result of the expression of the wrong enzyme during apoptosis, which occurs when the connective tissue is damaged or muscle tissue is damaged or improper growth, is produced by the immune system’s response to the BMP4 gene. As a result of the inability to prevent the production of the wrong enzyme in the immune system, these lymphocytes continue to be produced and ossification continues. On the one hand, the body tries to destroy these extra bones, which accelerates bone formation. As a result, an independent skeleton is formed like a normal skeletal structure. But this skeleton unites with the main skeletal system of the body (It should be noted, BMP4 is the gene that should not be active when it comes out of the mother’s womb. Also, this gene provides bone formation in the fetus).

Also, interestingly, muscles such as tongue, cardiac muscle, and diaphragm muscle are preserved in this process, meaning they do not ossify.

moriarty

What is Stone Man Syndrome ?

This disease, known as the Stone Man Syndrome, is the ossification of the connective tissue in the body (specialized tissues that connect the tissues to each other), particularly under pressure and impact. Those with this syndrome cannot do physical activity, because every stroke they take will ossify the affected area.

pessoa

In Stone Man Syndrome, medical interventions such as biopsy and vaccination accelerate the petrification process. People with this disease cannot even perform simple operations such as combing hair, hanging and getting their coat because of petrification.

flavianus

FOP (Fibrodysplasia Ossificans Progressiva) (progressive ossification of connective tissue) disease causes the conversion of connective tissue into bone. This is because the body repair mechanism is damaged by a mutation. The mutation gene is the ACVR1 gene. As a result of this mutation, endothelial cells turn into impregnated bone marrow cells and they turn into bone. As a result of injuries, those parts begin to freeze and ossify.

jimmyjones

What is the scientific name of Stone Man Syndrome ?

Fibrodysplasia Ossificans Progressiva is the scientific name of Stone Man Syndrome.

What is the reason for Stone Man Syndrome ?

A genetic mutation causes Stone Man Syndrome. This genetic mutation that causes this disease occurs spontaneously in the gametes. And individuals with this disease usually do not have children.

lumpenlife

Facts about Stone Man Syndrome

This disease was formerly known as Myositis Ossificans Progressiva (“ossification of muscles”). However, research has shown that not only muscles, but all connective tissue regions can be converted to bone. So in 1970 the name of this disease was changed to Fibrodysplasia Ossificans Progressiva.

belladona

Fibrodysplasia Ossificans Progressiva typically occurs first in the dorsal, axial, cranial and proximal regions of the body, and then progresses to the ventral, appendicular, tail and distal regions. Stone Man Syndrome, also known as Fibrodysplasia Ossificans Progressiva, is a very rare disorder.

dreamers

How is Stone Man Syndrome treated ?

There is no specific treatment for Fibrodysplasia Ossificans Progressiva. The resulting bone structures can be removed by surgery, but this process accelerates ossification even further. It was thought that the squalamine chemical discovered in sharks in 1999 could be a solution for FOP disease. This study started in 2002 and was canceled in 2007. So, we can say there is no treatment for Stone Man Syndrome.

manhattanboys

In Stone Man Syndrome, tendons, muscles and connective tissues in a person’s body convert to bone over time.

percussion

There is currently no treatment for Stone Man Syndrome. Scientists trying to find a solution to regress the disease process have difficulty in conducting their studies because the disease is rare and patients become fragile. However, alternative methods are currently being developed and work is underway to find a solution to this peculiar disease.

stockholmcity

What causes Stone Man Syndrome ?

Studies have shown that Stone Man Syndrome is caused by mutation in the ACVR1 gene. The ACVR1 gene normally serves to regulate the production of bone morphogenic protein. This protein is also found in our muscles and cartilage tissue and controls the development of our bones.

billythekid

What is Stone Man Syndrome ?

Stone Man Syndrome is a genetic disease. The main theme of the disease is the ossification of connective tissues in the body, especially in the face of impact and pressure. In fact, the active gene in the mother’s womb when it comes out is active. Under normal conditions this gene is likely to be inactive. The active gene creates a normal skeletal structure. However, it merges with the already existing skeletal structure. People with this disease, like normal people can not do physical activity.

wannabe

What causes Stone Man Syndrome ?

Stone Man Syndrome occurs as a result of a change in body repair mechanism and failure to fulfill its duties. This changed gene is ACVR1 gene. As a result of this change, endothelial cells turn into bone marrow cells and they turn into bone. As a result of the injuries that may occur, those areas begin to freeze. Most patients with Stone Man Syndrome do not have children.

johnnythewarrior

Is there any possible treatment for Stone Man Syndrome ?

In this terrible disease, where the body’s self-healing mechanism is mutated, when a patient is injured, the injured area does not heal. On the contrary, the soft tissues and muscles in his body break down under pressure and impact and ossify. So the body starts to fill and wrap the areas that it finds empty all the time with the bones it produces. Bones and joints around the joints and rib cages make it difficult to breathe, talk and eat. Taking the bones that have grown by surgery will cause more pressure in the body during the intervention and will cause the surgical area to fill with more bones and there is no surgical treatment.

mrweng

What is the average life span of people who suffer from Stone Man Syndrome ?

The patients suffer from Stone Man Syndrome cannot do any physical activity because each stroke will cause to ossification of some parts on the body. Impact elements include even strong winds or torrential rain. But whatever he does, he cannot prevent some blows, so the average life span of these people is 40 years. After a while the body turns unable to perform passive procedures such as drinking water, sitting and getting up, and eventually the person dies terribly.

kingofthequeens

Stone Man Syndrome is associated with the disruption of the body’s self-renewal mechanism, and the injured tissue regenerates itself as bone.

tigerisdown

What is Stone Man Syndrome ?

Stone Man Syndrome affects one in two million people worldwide. People suffering from Stone Man Syndrome, known as “Fibrodysplasia Ossificans Progressiva” in medical language, spend their whole lives avoiding minor injuries and fearing such accidents because they can advance their illness. Syndrome converts tendons, muscles and connective tissue in a person’s body to the bone over time.

pragmaticthoughts

Is there any treatment for Stone Man Syndrome ?

There is currently no treatment for Stone Man Syndrome. Scientists trying to find a solution to regress the disease process have difficulty in conducting their studies because the disease is rare and patients become fragile. However, alternative methods are currently being developed and work is underway to find a solution to this peculiar disease.

toptrend

What is the cause of Stone Man Syndrome ?

Studies have shown that stone man syndrome is caused by mutation in the ACVR1 gene. The ACVR1 gene normally serves to regulate the production of bone morphogenic protein. This protein is also found in our muscles and cartilage tissue and controls the development of our bones. Syndrome creates enormous difficulties in people’s lives.

ricardogarcia

What happens if you have Stone Man Syndrome ?

Stone Man Syndrome restricts mobility, blunt joints, and causes difficulties in feeding and breathing. The majority of people with a syndrome become bedridden when they reach the age of twenty and these people live on average for forty years.